Accupril



 
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Accupril - Basic Information

 

Indication of Accupril:

Accupril  is used in the treatment of hypertension and as an adjunct in the treatment of congestive heart failure.

Action of Accupril:

Accupril is an Angiotensin Converting Enzyme (ACE) Inhibitor. ACE- inhibitors interfere with a cascade of chemicals, leading to a decrease in the amount of chemicals that are responsible for causing the blood vessels in the body to constrict and for causing the kidneys to conserve salt and water. The vasodilatation of the blood vessels and the loss of salt and water from the kidneys causes the blood pressure to decrease. It may take up to two weeks for the maximum blood pressure lowering effects of Accupril to be seen in some patients.

Dose Advice of Accupril:

Hypertension: Initially the dosing should be 5-10mg once daily. This can then be increased at 4 week intervals to 10-40mg daily either once daily or in 2 divided doses a day. Congestive heart failure: Initally 5 mg daily and this can then be increased at weekly intervals to 10-20mg daily in 2 divided doses. In patients with renal impairment, concurrent diuretic therapy or who are elderly the initally dose whould be 25-5mg daily.

Schedule of Accupril:

Schedule 4

Common side effects of Accupril:

Cough: The cough produced by ACE-inhibitors is typically persistant, non-productive, dry and worse at night. It resolves after discontinuation of therapy. Hyperkalemia: ACE Inhibitors increase serum potassium levels by decreasing aldosterone production. Hyperkalemia is more likely to occur in patients with renal impairment, and patients who are taking potassium sparing diuretics (such as Spironolactone) or potassium supplements. These patients should have regular serum urea and electrolyte measurements.HeadacheDizzinessFatigueNauseaRenal impairment: In patients who are elderly, have pre-existing renal disease, are taking diuretics or NSAIDs, or who have limited cardiac reserve or bilateral renal artery stenosis inhibition of the Renin-Angiotensin-Aldosterone (RAA) system by ACE-inhibitors may impair renal function. Hypoglycemia can occur in diabetic patients taking ACE-inhibitors and blood glucose levels should be monitored

Uncommon side effects of Accupril:

RashPhotosensivitityPruritisTaste disturbances such as decreased taste sensitivity, or metallic tastes can occur during the first few weeks of treatment but usually disappear within 1-3 months.PalpitationsChest painFlushingFeverVomitingAnorexiaDiarrhoeaConstipationStomatitisDry mouthSore throatVoice hoarsenessMuscle crampsElevated hepatic transaminasesElevated bilirubinProteinuriaMyalgiaArthralgia

Diseases treated by Accupril:

Diabetic Nephropathy

Treatments associated with Accupril:

Angiotensin-converting Enzyme Inhibitors (ACE inhibitors, ACEi) (Angiotensin-converting Enzyme Inhibitors (ACEi))


GN: Quinapril hydrochloride

Con: hypertension

Cla: Angiotensin-converting Enzyme Inhibitors (ACE...