Indication of Adefin:
-Hypertension
Action of Adefin:
-Nifedipine is a calcium channel blocker. It inhibits the slow inward calcium ion channels -It is a relaxant of vascular smooth muscle and an inhibitor of coronary artery spasm thus improving myocardial oxygen supply. -It inhibits the influx of calcium ions causing relaxation and peripheral vasodilatation, which in turn reduces the afterload against which the heart works. -It directly decreases myocardial oxygen consumption. -Reduction in blood pressure is mediated by relaxation of vascular smooth muscle and resultant decrease in peripheral vascular resistance.
Dose Advice of Adefin:
-Hypertension: Initial dose is 10-20 mg twice daily. Dose can be increased to 40 mg twice daily if needed -Recommended dose interval is about 12 hours -Patients with hepatic impairment should commence therapy at 10 mg twice daily with careful supervision -In cases of severe overdosage – disturbances of consciousness, drop in blood pressure, tachycardic/bradycardic rhythm disturbance, hyperglycaemia, metabolic acidosis, cardiogenic shock with pulmonary edema can occur.
Schedule of Adefin:
Schedule 4
Common side effects of Adefin:
-Peripheral oedema -Hypotension -Dizziness -Flushing -Numbness -Tingling -Tiredness -Nausea -Vomiting -Heartburn -Dyspepsia -Headache
Uncommon side effects of Adefin:
-Auditory - tinnitus -Cardiovascular - tachycardia, chest pain, ischaemia -Gastrointestinal – abdominal pain, diarrhoea, gum alterations -Dermatological – exfoliative dermatitis, pruritus, urticaria -Nervous system – acute psychosis, tremor, myalgia, -Others – allergic hepatitis, hyperglycaemia, thrombocytopaenia, anaemia, leucopenia, gynaecomastia, transaminase increases, intrahepatic cholestasis, polyuria, glomerulonephritis, nephrotic syndrome, increased asthmatic symptoms after cessation of therapy in patients with chronic obstructive lung disease.
