Augmentin - Basic Information


Indication of Augmentin:

Hospital acquired pneumoniaEpididymo-orchitisRecurrent urinary tract infectionBites and clenched fist injuriesOtitis media (unresponsive to amoxicillin)

Action of Augmentin:

Bactericidal; penicillins interfere with bacterial cell wall peptidoglycan synthesis.Moderate spectrum penicillins like amoxicillin are active primarily against gram positive organisms.The addition of clavulanic acid to amoxicillin extends spectrum of activity to cover many beta-lactamse producing gram positive (S. aureus) and gram negative organisms (Moraxella Catarrhalis, H. Influenzae, Proteus spp, E. coli, Klebsiella spp), including gram negative anaerobes.

Dose Advice of Augmentin:

Oral liquid (powder for) Amoxicillin 25mg/mL, Clavulanic acid 6.25mg/mL, 75mLDoses are based on the amoxicillin component.Adult: 250-500mg every 8 hours (or using Duo formulations: 500-875 mg every 12 hours) for 5-10 days.Child: 7.5-15mg/kg every 8 hours (or using Duo formulations 225mg/kg every 12 hours) for 5-10 days.Moderate renal impairment: Adult: give normal initial dose then 500mg every 12 hoursSevere renal impairment: Adult: give normal initial dose then 500mg every 24 hours

Schedule of Augmentin:


Common side effects of Augmentin:

Penicillins are generally well toleratedDiarrhoeaNauseaRashUrticariaSuperinfection- especially during prolonged treatment and/or broad spectrum antibioticsTransient increases in liver enzymes and bilirubin

Uncommon side effects of Augmentin:

BronchospasmFeverVomitingErythemaExfoliative dermatitisAngioedemaStevens Johnson SyndromeToxic epidermal necrolysisPseudomembranous colitis

Diseases treated by Augmentin:

Dental Pain Epididymitis and Orchitis (epididymo-orchitis) Otitis Media (Middle Ear Infection) Severe Acute Respiratory Syndrome (SARS)

Con: pneumonia