Indication of Capastat:
Capastat is used in conjunction with other drugs in the treatment of tuberculosis (TB) when the primary agents used for this condition (isoniazid, rifampicin, ethambutol, aminosalicylic acid and streptomycin) have been unsuccessful or cannot be used because of toxicity or resistance. Studies of Mycobacterium tuberculosis isolated from the patient should be performed to ensure it is susceptible to Capastat before treatment is started
Action of Capastat:
Capastat is an anti-tuberculosis agent that has been derived from another bacteria, Streptomyces capreolus. By a mechanism that is not fully understood, it is active against the bug that causes tuberculosis, Mycobacterium tuberculosis.
Dose Advice of Capastat:
Capastat is for intramuscular injection only and should not be injected or infused intravenously. It should be given as a deep injection into a large muscle mass to prevent superficial pain and abscess formation. Dissolve powder in 2ml water for injection or 0.9% sodium chloride and allow 2-3 minutes for complete dissolution. Dosage-1g daily (not exceeding 20mg/kg/day) intramuscularly for 60-120 days-then 1g intramuscularly 2-3 times a week-this therapy should be maintained for 12-24 monthsImpaired renal function-dosage adjustment should be made depending on creatinine clearance, aiming to achieve a steady state Capreomycin level of 10
