Cardizem



 
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Cardizem - Basic Information

 

Indication of Cardizem:

-Mild to moderate essential hypertension -Chronic stable angina

Action of Cardizem:

-Diltiazem is a slow calcium channel blocker. -It inhibits the influx of calcium ions during membrane depolarisation of cardiac and vascular smooth muscle.-Reduction in blood pressure is mediated by relaxation of vascular smooth muscle and resultant decrease in peripheral vascular resistance.

Dose Advice of Cardizem:

-Hypertension: Initial dose is 180-240 mg once daily. Maximum effect usually seen by 14 days of therapy. Dosage can be thus adjusted every 2 weeks. Maintenance dose is 240-360 mg/day.-Angina: Initial dose is 180 mg daily and maximum is 360 mg daily. Dose should be titrated over 7-14 days.

Schedule of Cardizem:

S4

Common side effects of Cardizem:

-Oedema-Headache-Dizziness-Asthenia-First degree atrioventricular block-Bradycardia-Flushing-Nausea-Rash-Dyspepsia

Uncommon side effects of Cardizem:

-Cardiovascular - angina, arrythmia, atrioventricular block, bundle branch block, congestive heart failure, hypotension, syncope, tachycardia-Nervous system


GN: Diltiazem hydrochloride