Combivent Metered Dose Aerosol



 
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Combivent Metered Dose Aerosol - Basic Information

 

Indication of Combivent Metered Dose Aerosol:

Used for maintenance treatment in COPD in patients insufficiently controlled by single bronchodilator

Action of Combivent Metered Dose Aerosol:

Salbutamol component: Relax bronchial smooth muscle by stimulating beta 2 adrenoreceptorsOnset of action (5-15 minutes)Short duration of action (3-6 hours)Ipratropium component: Promote bronchodilation by inhibiting cholinergic bronchomotor toneDuration of action of Ipratropium is approximately 6 hours, thus it can be used to augment the duration of bronchodilatation achieved with beta 2 agonist therapy.

Dose Advice of Combivent Metered Dose Aerosol:

(metered dose inhaler) Ipratropium 20mcg with Salbutamol 100mcg/dose, 200 dosesMDI: 2 inhalations, 4 times daily. Maximum dose 12 inhalations in 24 hours.

Schedule of Combivent Metered Dose Aerosol:

S4

Common side effects of Combivent Metered Dose Aerosol:

Salbutamol component: TremorPalpitationsHeadacheIpratropium component: Dry mouthThroat irritation

Uncommon side effects of Combivent Metered Dose Aerosol:

Salbutamol component: Increased heart rate (which can also lead to paroxysmal tachyarrhythmias such as atrial fibrillation or paroxysmal supraventricular tachycardia)Muscle crampsAgitationHyperactivity in childrenInsomniaHyperglycaemia (high blood sugar) and hypokalaemia (low blood potassium) when drug taken in high dosesIpratropium component: Urinary retention (there is a risk of aggravation of symptoms in patients with prostatic hypertrophy)Acute angle closure glaucoma (there is a risk of aggravation of symptoms in patients with coexisting glaucoma)ConstipationAllergic reactions (Ipratropium MDI should not be used by patients with allergy to soya lecithin or related food products such as soya bean and peanuts)

Diseases treated by Combivent Metered Dose Aerosol:

Asthma