Dacarbazine for Injection

Indication of Dacarbazine for Injection (DBL):

Darcarbazine is used in the treatment of the following malignancies: Metastatic malignant melanomaEwings sarcomaRhabdomyosarcoma Hodgkins disease

Action of Dacarbazine for Injection (DBL):

Dacarbazine interferes with cellular replication by forming cross-linkages between DNA strands.

Dose Advice of Dacarbazine for Injection (DBL):

Specialist protocols should be consulted concerning dosages: Melanoma: An initial dose that may be used is 250 mg/m2 daily given by intravenous infusion on days 1-5 of each 21-day cycle. Alternatively, 800 mg/m2 can be given on day 1 of each 21-day cycle.These doses may be used in single or combination therapy.Subsequent doses depend on the individual patients response and the severity of adverse effects.Hodgkins disease: Dacarbazine is used in combination treatment with other antineoplastic agents.150 mg/m2 each day given by intravenous infusion on days 1-5 of each 28-day cycle.Alternatively, 375 mg/m2 can be given on day 1 and day 15 of each 28-day cycle.

Schedule of Dacarbazine for Injection (DBL):

S4

Common side effects of Dacarbazine for Injection (DBL):

Bone marrow suppressionNauseaVomitingDiarrhoeaFeverMuscle achesFatigueFacial flushingPain along the injected vein

Uncommon side effects of Dacarbazine for Injection (DBL):

Low white cell countBlurred visionHair lossConfusionHeadacheRashIncreased sensitivity of skin to lightSeizuresFor more health information on Dacarbazine for Injection (DBL) consult your local doctor.

Diseases treated by Dacarbazine for Injection (DBL):

Hodgkins Lymphoma

• D.t.i.c
• Dacarbazine for injection

• Blenamax
• Blenoxane
• D.t.i.c
• Dacarbazine for injection
• Natulan
• Oncovin