Indication of Endep:
Endep is used for: Major depression.Bed-wetting, urge incontinence.Adjunct in pain management.
Action of Endep:
Tricyclic antidepressants (TCAs) exert their effects by inhibiting the re-uptake of noradrenaline and serotonin into presynaptic terminals.
Dose Advice of Endep:
Depression in adults: 25-75mg daily, increasing by 25-50mg every 2-3 days to 75-150mg daily. Maximum 300mg daily.Urinary urge incontinence: 10-25mg 1-3 times daily.Nocturnal enuresis in children: Child 7-10 years- 10-20mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.Child older than 10 years- 25-50mg 30-60 minutes before bedtime; maximum period of treatment is 3 months.Do not use for enuresis (Involuntary urination) in children under 7 years.
Schedule of Endep:
S4
Common side effects of Endep:
See uncommon side effects.
Uncommon side effects of Endep:
Sedation.Dry mouth.Blurred vision.Constipation.Weight gain.Orthostatic hypotension.Urinary hesitancy or retention.Reduced gastrointestinal motility.Anticholinergic delirium (particularly in the elderly and in Parkinsons Disease.Impotence.Loss of libido.Other sexual adverse effects.Tremor. Dizziness.Sweating.Agitation.Insomnia.
Diseases treated by Endep:
Cancer pain Cervical Root disorders (cervical spondylotic myelopathy & radiculopathy) Diabetic Neuropathy Fibromyalgia (Fibrositis Syndrome) Meralgia Paraesthetica Neuropathic Pain Peripheral Neuropathies Phantom Limb Pain Tension headache
