Indication of Fasturtec:
Fasturtec is used in the prevention and treatment of acutely raised uric acid levels that occur when large number of cancer cells are killed and release their cellular contents (tumour lysis syndrome).
Action of Fasturtec:
When chemotherapy kills large numbers of tumour cells, uric acid is released and builds up in the blood. This can lead to renal damage and even renal failure. Fasturtec is an enzyme, which converts uric acid into more easily excreted metabolites. This decreases the risk of renal damage.
Dose Advice of Fasturtec:
Rasburicase should be administered immediately prior to and during chemotherapy that is expected to cause tumour lysis syndrome. Recommended dose: 0.20mg/kg/dayadminister as 30 minute infusion in 50ml sodium chloride 0.9%treat for 5-7 daysadminister through a separate intravenous line to chemotherapy agentsdiscard any residuechemotherapy should be administered as normal, no change to the regimen is necessary.
Schedule of Fasturtec:
S4
Common side effects of Fasturtec:
FeverNauseaVomitingRash
Uncommon side effects of Fasturtec:
DiarrhoeaHeadacheAllergic reactions including bronchospasmHaemolytic anaemia in "at risk" populations, such as those with G6PD deficiency.Methaemoglobinaemia in "at risk" populations.
Reference:
Bochner F, Hill R, Nation R, et. al. The Australian Medicines Handbook [Online]. 2005 [cited July 2005]. Available from URL: http: //www.ciao.health.wa.gov.au.MIMS Australia. MIMSOnline Prescribing Information: Fasturtec [Online]. 2003 [cited 29/10/2003]. Available from URL: http: //proxy8.use.hcn.com.au/ifmx-nsapi/mims-data/?MIval=2MIMS_abbr_pi&product_code=6380&product_name=FasturtecSanofi-Synthelabo Australia Pty Limited Fasturtec Consumer Medicine Information. North Ryde, New South Wales: Sanofi-Synthelabo Australia Pty Limited; 2002Sanofi-Synthelabo Australia Pty Limited Fasturtec Product Information. North Ryde, New South Wales: Sanofi-Synthelabo Australia Pty Limited; 2003
Diseases treated by Fasturtec:
Lymphoma of the Brain Tumour Lysis Syndrome
