Gantin



 
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Gantin - Basic Information

 

Indication of Gantin:

This drug is used in the management of epileptic partial seizures including secondarily generalized tonic clonic seizures for patients not adequately controlled with standard anti-epileptic drugs (it is used in addition to standard therapy).Gabapentin can also be used for the treatment of neuropathic pain.

Action of Gantin:

The way in which gabapentin exerts its anticonvulsant effect is unknown.The drug is structurally related to the neurotransmitter GABA (gamma-aminobutyric acid) but its mechanism of action differs to other drugs that interact with GABA synapses.The binding site of gabapentin is yet to be established It also does not affect sodium channels, a means by which other anticonvulsants may work.

Dose Advice of Gantin:

Epilepsy: Treatment should be initially given as add-on therapy to standard anti-epileptic medicationIt can be given orally with or without foodEvidence has shown that the effective dose range is 900-1800mg/day in divided dosesDosage initially begins by administering 300mg capsules, three times daily Alternatively the dose may be titrated with 300mg being administered on day 1, 300mg twice on day 2 and 300mg three times on day 3 - this method may be more effective in patients with renal impairment, encephalopathy, multiple anti-epileptic use or other medical problems.Neuropathic pain: Initial dosage is 900mg/day in three equally divided doses This may be titrated if need beMaximum dosage should be 3,600mg/dayImpaired kidney function: Dosage adjustment may be necessary for patients undergoing dialysis or those with impaired renal function.Children: The effective dose of gabapentin for children is 25-35mg/kg/day three divided doses.

Schedule of Gantin:

S4

Common side effects of Gantin:

dizzinesssomnolenceataxiafatiguenystagmus (abnormal eye movement)nausea and vomitingweight gaindifficulty swallowingmuscle paintremornervousnesscough and rhinitispharyngitisswelling

Uncommon side effects of Gantin:

feverinfectionabdominal painconstipationdiarrhoeaamnesiadepressionconfusioninsomniarashblood pressure increaseflatulencegingivitisvertigoabnormal vision

Diseases treated by Gantin:

Fibromyalgia (Fibrositis Syndrome)


GN: Gabapentin

Con: epileptic