Indication of Inspra:
Treatment of high blood pressure.Reduces the risk of congestive heart failure if used 3-14 days after a heart attack.
Action of Inspra:
Eprelenone is an inhibitor of the mineralocorticoid receptor, this is the receptor in the body responsible for the action of aldosterone, a steroid hormone. Aldosterone increases blood pressure mainly by retaining sodium and water, therefore inhibition of the receptor where this hormone works reduces blood pressure.
Dose Advice of Inspra:
Hypertension 50mg once daily, if patient doesnt respond use 50mg twice daily.Congestive Heart Failure 25mg daily increasing to 50mg within 4 weeks.
Schedule of Inspra:
S4 - prescription only.
Common side effects of Inspra:
HypotensionDizzinessDiarrhoea, nauseaHigh potassiumAltered Renal function
Uncommon side effects of Inspra:
Postural hypotensionBack painMalaiseLeft sided cardiac failureAtrial fibrillationDehydrationIncreased cholesterol and triglyceride levelsLow sodium
Inspra URL: :
www.inspra.com.au
Reference:
Inspra - Prescribing information [online], MIMS, 2006, Available at URL: http: //www.mims.com.au (last accessed 06/02/2006)Uptodate Inspra product information [online], Uptodate, 2006, Available at URL: http: //www.uptodate.com (last accessed 06/02/2006)
Diseases treated by Inspra:
Heart Attack (Myocardial Infarction)
