Indication of Kalma:
Anxiety, including anxiey with symptoms of depressionPanic disorder
Action of Kalma:
Benzodiazepines potentiate the inhibitory effects of gamma aminobutyric acid (GABA throughout the CNS, resulting in anxiolytic, sedative hypnotic, muscle relaxant and antiepileptic effects
Dose Advice of Kalma:
Anxiety: Initially 0.25-0.5mg 3 times daily. Range 0.5-4mg dailyPanic disorder: Initially 0.5-1mg at night, increased by 0.25-1mg every 3 days until symptoms are controlledMaximum 10mg dailyElderly and/or debilitated patient: Initially 0.25mg 2-3 times daily
Schedule of Kalma:
S4
Common side effects of Kalma:
DrowsinessOver-sedationLight-headednessMemory lossAtaxiaSlurred speech
Uncommon side effects of Kalma:
HeadacheVertigoHypotensionDisorientationConfusionParadoxical excitationEuphoriaAggression and hostilityAnxietyDecreased libido Anterograde amnesiaPain and thrombophlebitis with IV injectionRespiratory arrest with IV use
