Indication of Keppra:
Keppra (levetiracetam) is an antiepileptic medicine used to control the excessive electrical activity in the brain that results in epileptic seizures. The brain and nerves are made up of many nerve cells that communicate with each other through electrical signals. These signals must be carefully regulated for the brain and nerves to function properly. When abnormally rapid and repetitive electrical signals are released in the brain, it becomes over-stimulated and normal function is disturbed This results in fits or seizures. Keppra is used to treat partial seizures, with or without generalised seizures. It is usually used in combination with other antiepileptic drugs when control is inadequate.
Action of Keppra:
It is not fully understood how Keppra works to control seizures, but its mechanism appears to be different from other antiepileptic medicines. It is used in combination with other treatments to control epilepsy.
Dose Advice of Keppra:
Tablets should be swallowed whole, with or without food. Adults and adolescents older than 16 years: The recommended starting dose is 500mg twice daily.This dose may be increased to a maximum of 1500mg twice daily depending on clinical response and tolerance.Special considerations: Dosage adjustment is recommended in those with impaired kidney function. This may include some elderly patients.
Schedule of Keppra:
S4
Common side effects of Keppra:
Levetiracetam is associated with some side effects. You should discuss these with your doctor. Common side effects, which may occur in up to 10% of patients taking this medication, include: Behavioural changes, including agitation, aggression, anxiety, depression, or irritability; Headache;Excessive sleepiness (somnolence) or insomnia;Nausea and vomiting or loss of appetite;Weakness or loss of strength;Cough; Accidental injury; andInfection.
Uncommon side effects of Keppra:
Uncommon side effects of this medication (occurring in less than 1 in 10 patients) include: Pain;Dizziness;Amnesia (memory loss);Rash or bruising;Diarrhoea or constipation; andSore throat.Very rarely, Keppra may be associated with an increased risk of suicidal ideation or attempted suicide.
Reference:
AMH Pty Ltd. Levetiracetam. Australian Medicines Handbook: July, 2006. Lexi-Comp, Inc. Levetiracetam: Drug information [online], UpToDate.com. 2006. Available at URL: http: //www.uptodate.com (last accessed 30/9/06)MIMS Australia Pty Ltd. Keppra. MIMS Online 2003 Available from: http: //www.mims.com.au
Diseases treated by Keppra:
Epilepsy
Treatments associated with Keppra:
Antiepileptics (Antiepileptics)
