Leukeran

Indication of Leukeran:

Chlorambucil is used in the treatment of - Hodgkins lymphoma.- Non-Hodgkins lymphoma.- Chronic lymphocytic leukaemia.- Waldenstroms macroglobulinaemia.- Advanced ovarian adenocarcinoma.- Breast cancer.- Nephrotic syndrome.- Systemic lupus erythematosus.- Lupus nephritis.- Immune-related ocular disease.- Multiple myeloma.

Action of Leukeran:

Chlorambucil acts by preventing replication of tumour cells by forming cross-linkages between DNA strands.

Dose Advice of Leukeran:

Specialist protocols should be consulted For the treatment of neoplasms initial doses of 100?200 micrograms/kg per day orally have been used if Chlorambucil is used as a single agent.Further courses and doses depend on the individual patient?s response and side effects.If Chlorambucil is used as an immunosuppressant 100?200 micrograms/kg is given once daily orally. Renal impairment: Doses should be reduced in patients with moderate to severe renal impairment. If creatinine clearance is less than 20 ml/minute, doses should be halved Pregnancy: Chlorambucil can cause spontaneous abortion, foetal loss and birth defects and should be avoided during pregnancy. It should also be avoided during breastfeeding.

Schedule of Leukeran:

S4

Common side effects of Leukeran:

- Bone marrow suppression.- Hair loss.- Increased sensitivity of skin to light.

Uncommon side effects of Leukeran:

- Abdominal discomfort.- Nausea.- Vomiting.- Diarrhoea.- Mouthy ulceration.- Hallucinations.

Diseases treated by Leukeran:

Waldenstroms Macroglobulinemia

Treatments associated with Leukeran:

Immunosuppressants in organ transplantation (Immunosuppressants in organ transplantation)

• Leukeran

• Leukeran
• Leustatin

• Cycloblastin
• Imuran
• Leukeran
• Methoblastin
• Neoral
• Puri-nethol
• Simulect