Maosig



 
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Maosig - Basic Information

  • GN: Moclobemide
  • Con: information not available
  • Cla: information not available
 

Indication of Maosig:

Major depression Panic disorder Social phobia

Action of Maosig:

Competitive and reversible inhibition of monoamine oxidase (MAO). It is relatively selective for type A (MAO-A). Synaptic concentrations of serotonin, noradrenaline, and dopamine are increased Full activity of the MAO-A enzyme is restored within 24-48 hours of stopping the drugWhen used at higher than recommended doses, moclobemide will also inhibit MAO-B (dietary restrictions would then be warranted)

Dose Advice of Maosig:

Initially 300mg daily in 1 or 2 divided doses, increasing after 2 weeks.Maintenance 450-600mg daily in 1 or 2 divided doses. Usual maximum dose 600mg daily

Schedule of Maosig:

S4

Common side effects of Maosig:

NauseaDry mouthConstipationDiarrhoeaAnxietyRestlessnessInsomniaDizzinessHeadache

Uncommon side effects of Maosig:

Visual disturbancesGastrointestinal complaints (feeling of fullness)RashItchUrticariaFlushingRare: Sedation


GN: Moclobemide