Nardil



 
Options
Vote
Comments

Nardil - Basic Information

 

Indication of Nardil:

Major depression (second line)Some anxiety disorders including phobic disorders and panic disorder (second line)

Action of Nardil:

Irreversible, non-selective inhibition of the enzymes, monoamine oxidase-A and monoamine oxidase-B. This action leads to elevation of synaptic concentrations of adrenaline, noradrenaline, dopamine and serotonin in the brain and other tissues. The duration of action is 2-3 weeks while new enzymes form.

Dose Advice of Nardil:

45-90mg daily in 2 or 3 divided doses. Reduce to lowest effective dose for maintenance once a response is obtained Maximum 90mg daily.

Schedule of Nardil:

S4

Common side effects of Nardil:

Orthostatic hypotensionSleep disturbance- including insomnia and less commonly hyprsomnia.HeadacheDrowsinessFatigueWeaknessAgitationTremorsTwitchingMyoclonusHyperreflexiaConstipationDry mouthWeight gain ImpotenceLoss of libidoElevated serum transaminases

Uncommon side effects of Nardil:

ItchRashSweatingBlurred visionPeripheral oedemaManiaHypertensive crisis (tyramine or medication interactions)- patients should promptly report headaches or other unusual symptoms to their doctor. Stop taking the medicine immediately if palpitations or severe headache occur and seek medical attention urgently.

Diseases treated by Nardil:

Bulimia Nervosa Dissociative Disorders


GN: Phenelzine sulfate

Con: depression