Indication of Orap:
Treatment of acute and chronic psychoses. Tourettes syndrome and other choreas.
Action of Orap:
Blockade of dopaminergic transmission in various parts of the brain by antagonizing D2 receptors, which results in anti-psychotic effects, including relief from symptoms such as hallucinations, delusions or abnormal behaviour/thought.
Dose Advice of Orap:
Adult: 2-12mg daily, maximum 20mg daily (use daily doses >12mg under specialist supervision only).Child Tourettes syndrome: Initially 1-2mg daily, maximum 0.2mg/kg daily.
Schedule of Orap:
S4
Common side effects of Orap:
Anticholinergic effects: dry mouth, blurred vision, constipation, tachycardia, urinary hesitancy, increased intraocular pressure, nausea and vomiting, sexual adverse effects.Orthostatic hypotension.Sedation.Extrapyramidal effects (Parkinsonism, Akathisia, Dystonias, Tardive dyskinesia).Hyperprolactinaemia (may result in galactorrhoea, gynaecomastia, amenorrhoea or infertility).
Uncommon side effects of Orap:
Allergic reactionsPigmentary changes of skin or eyesCorneal and lens opacitiesHypothermiaHyperthermiaSIADH
Diseases treated by Orap:
Tardive Dyskinesia
Treatments associated with Orap:
Conventional Antipsychotics (Conventional Antipsychotics)
