Indication of Parnate:
Major depression (second line)
Action of Parnate:
Irreversible, non-selective inhibition of the enzymes, monoamine oxidase-A and monoamine oxidase-B. This action leads to elevation of synaptic concentrations of adrenaline, noradrenaline, dopamine and serotonin in the brain and other tissues. The duration of action is 2-3 weeks while new enzymes form
Dose Advice of Parnate:
20-40mg daily in 2 or 3 divided doses. Reduce to lowest effective dose for maintenance once a response is obtained Maximum 60mg daily
Schedule of Parnate:
S4
Common side effects of Parnate:
Orthostatic hypotensionSleep disturbance- including insomnia and less commonly hyprsomniaHeadacheDrowsinessFatigueWeaknessAgitationTremorsTwitchingMyoclonusHyperreflexiaConstipationDry mouthWeight gain ImpotenceLoss of libidoElevated serum transaminases
Uncommon side effects of Parnate:
ItchRashSweatingBlurred visionPeripheral oedemaManiaHypertensive crisis (tyramine or medication interactions)- patients should promptly report headaches or other unusual symptoms to their doctor. Stop taking the medicine immediately if palpitations or severe headache occur and seek medical attention urgently
