Indication of Paxtine:
Major depression Obsessive-compulsive disorderPanic disorderGeneralised anxiety disorderPost-traumatic stress disorderSocial phobia
Action of Paxtine:
Antidepressant action by selective inhibition of pre-synaptic uptake of serotonin (5- hydroxytryptamine, 5-HT), thus increasing the levels of this neurotransmitter in the brain
Dose Advice of Paxtine:
Major depression: 20mg once daily, gradually increasing as necessary to a maximum of 50mg once daily. Use of maintenance doses of >20mg is not usually necessaryObsessive compulsive disorder; social phobia; generalized anxiety disorder; post-traumatic stress disorder: 20mg once daily, gradually increasing as necessary to a maximum of 50mg once daily.Panic disorder: Start at 10mg daily, increasing if necessary to 10mg after a week to 20mg once daily. Use of maintenance doses >20mg is not routinely necessary
Schedule of Paxtine:
S4
Common side effects of Paxtine:
NauseaAgitationInsomniaDrowsinwssTremorDry mouthDiarrhoeaDizznessHeadacheSweatingAstheniaAnxietyWeight gain or lossSexual dysfunctionRhinitisMyalgiaRash
Uncommon side effects of Paxtine:
Extrapyramidal reactions (including tartive dyskinesia and dystonia)SedationConfusionPalpitationsTachycardiaHypotensionSIADHAbnormal platelet aggregation/ haemorrhagic complications (e.g. bruising, epistaxis, purpura)Rare: Elevated liver enzymesHepatitisHepatic failureGalactorrhoeaBlood dyscrasiasSeizuresAkathesia
