Indication of Rapilysin:
This drug is used as thrombolytic (clot dissolving) therapy of acute myocardial infarction or heart attack (usually within 6 hours after the onset of symptoms).
Action of Rapilysin:
Reteplase is a recombinant plasminogen activator that catalyses the cleavage of endogenous plasminogen to generate plasmin.Plasmin is an endogenous agent that degrades fibrin and finrinogen which are the major components of thrombi (a clot in the blood vessels).This degradation of fibrin and fibrinogen breaks down the thrombus thus improving circulation (thereby restoring blood flow).
Dose Advice of Rapilysin:
Reteplase should be administered as a 10 + 10 U (unit) double bolus injection via an intravenous line.Each bolus is administered as slow intravenous injections of no longer than two minutes.The second bolus should be administered 30 minutes after the first bolus.
Schedule of Rapilysin:
S4
Common side effects of Rapilysin:
haemorrhage or bleedinghypotension or low blood pressure
Uncommon side effects of Rapilysin:
bleeding: gastrointestinal, gingival, urinary, cerebralallergic reactionsirregular heart rhythmsshocknauseavomitingfevereye haemorrhagelocal reaction at injection site
Diseases treated by Rapilysin:
Heart Attack (Myocardial Infarction)
