Sandimmun



 
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Sandimmun - Basic Information

 

Indication of Sandimmun:

Indications for the use of Cyclosporine include: Prevention of organ rejection after kidney, liver, and heart transplantationSevere active rheumatoid arthritisSevere psoriasisSevere atopic dermatitis Autoimmune diseases Nephrotic syndromePrevention of graft-versus-host diseasePotential organ transplant recipients that are receiving a blood transfusion may also require cyclosporine

Action of Sandimmun:

Cyclosporine acts by preventing the activation of the cells that are responsible for the production of an immune response in the body.

Dose Advice of Sandimmun:

Organ transplantation: 8-15 mg/kg orally per day given as 2 divided doses.If given with diltiazem 5?8 mg/kg orally per day given as 2 divided dosesAutoimmune diseases: 25-5 mg/kg orally per day given as 2 divided doses.Severe ulcerative colitis: 3-5 mg/kg intravenously daily.Prevention of allogenic graft-versus-host disease: 3 mg/kg intravenously daily until oral treatment can be tolerated

Schedule of Sandimmun:

S4

Common side effects of Sandimmun:

High blood pressureHigh cholesterol levelsTremorNumbness and tingling in the fingers and toesIncreased risk of infectionGum overgrowthIncreased body hairDiarrhoeaElevated blood sugar levelsKidney function impairment

Uncommon side effects of Sandimmun:

HeadacheMuscle weakness

Diseases treated by Sandimmun:

Behcets Disease (BD, and Silk Route disease)


GN: Cyclosporin

Con: Rheumatoid arthritis