Indication of Talohexal:
Major depression
Action of Talohexal:
Selective inhibition of pre-synaptic uptake of serotonin (5- hydroxytryptamine, 5-HT)SSRIs inhibit liver cytochrome enzymes responsible for the metabolism of many other drugs, thus potentially interacting with those drugs by decreasing their metabolism
Dose Advice of Talohexal:
20mg once daily, gradually increasing if necessary to a maximum of 60mg daily (40mg in the elderly).Maintenance doses > 20mg are not usually necessary
Schedule of Talohexal:
S4
Common side effects of Talohexal:
NauseaAgitationInsomniaDrowsinessTremorDry mouthDiarrhoeaDizznessHeadacheSweatingAstheniaAnxietyWeight gain or lossSexual dysfunctionRhinitisMyalgiaRash
Uncommon side effects of Talohexal:
Extrapyramidal reactions (including tartive dyskinesia and dystonia)SedationConfusionPalpitationsTachycardiaHypotensionSIADHAbnormal platelet aggregation/ haemorrhagic complications (e.g. bruising, epistaxis, purpura)Rare: Elevated liver enzymesHepatitisHepatic failureGalactorrhoeaBlood dyscrasiasSeizuresAkathesia
