Tamoxen



 
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Tamoxen - Basic Information

 

Indication of Tamoxen:

Tamoxifen is used in the palliative treatment of breast cancer that has been shown to express oestrogen receptors.

Action of Tamoxen:

Tamoxifen is a non-steroidal anti-oestrogen. It probably works by binding to oestrogen receptors, and this inhibits the effects of endogenous oestrogen. Many breast cancers have oestrogen receptors and therefore have their growth stimulated by the presence of oestrogen. By inhibiting oestrogen, Tamoxifen inhibits tumour growth.

Dose Advice of Tamoxen:

Initial dose is 20mg once daily. If no improvement is seen within one month, increase to 40mg daily.

Schedule of Tamoxen:

S4

Common side effects of Tamoxen:

-hot flushes-nausea-vomiting

Uncommon side effects of Tamoxen:

-fluid retention -vaginal bleeding-vaginal discharge-vaginal itching-tumour pain-tumour flare-lightheadedness-headaches-skin rash-hair lossIncreased occurrence of endometrial (lining of uterus) changes have been reported These range from polyps to cancer. Unusual vaginal bleeding should be immediately reported to your doctor.Visual changes may occur rarely.

Diseases treated by Tamoxen:

Peyronies Disease


GN: Tamoxifen citrate

Con: Peyronies disease