Indication of Tamoxifen (Terry White Chemists):
Tamoxifen is used in the palliative treatment of breast cancer that has been shown to express oestrogen receptors.
Action of Tamoxifen (Terry White Chemists):
Tamoxifen is a non-steroidal anti-oestrogen. It probably works by binding to oestrogen receptors, and this inhibits the effects of endogenous oestrogen. Many breast cancers have oestrogen receptors and therefore have their growth stimulated by the presence of oestrogen. By inhibiting oestrogen, Tamoxifen inhibits tumour growth.
Dose Advice of Tamoxifen (Terry White Chemists):
Initial dose is 20mg once daily. If no improvement is seen within one month, increase to 40mg daily.
Schedule of Tamoxifen (Terry White Chemists):
S4
Common side effects of Tamoxifen (Terry White Chemists):
-hot flushes-nausea-vomiting
Uncommon side effects of Tamoxifen (Terry White Chemists):
- fluid retention -vaginal bleeding-vaginal discharge-vaginal itching-tumour pain-tumour flare-lightheadedness-headaches-skin rash-hair lossIncreased occurrence of endometrial (lining of uterus) changes have been reported These range from polyps to cancer. Unusual vaginal bleeding should be immediately reported to your doctor.Visual changes may occur rarely.
