Taxotere



 
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Taxotere - Basic Information

 

Indication of Taxotere:

Taxotere is used in the treatment of advanced cancers where other chemotherapy regimens have failed It is used for: treatment locally advanced or metastatic breast cancer in combination with capecitabine after the failure of anthracycline chemotherapyadjuvant treatment of node positive breast cancer in combination with doxorubicin and cyclophosphamidetreatment in combination with trastuzumab of metastatic breast cancer where the tumour overexpresses HER2 and it has not previously received chemotherapy for metastasestreatment of metastatic or locally advanced non-small cell lung cancer including those that have failed platinum-based chemotherapytreatment of metastatic carcinoma of the ovaries where first line or subsequent chemotherapy has failedtreatment of androgen independent (hormone refractory) prostate cancer

Action of Taxotere:

Docetaxel is an antimetabolite agent known as a taxane. Taxanes are cytotoxic agents that work on a molecule called tubulin. Tubulin is a protein important in the building of microtubules, which are vital in separation of chromosomes during cell division. Taxanes cause tubulin to be assembled into non-functional microtubules, which cells then cant disassemble. The non-functional microtubules cause the cells to become stranded halfway through cell division.

Dose Advice of Taxotere:

The required dosage of taxotere is complex. Consult your doctor.

Schedule of Taxotere:

S4

Common side effects of Taxotere:

Rashsensitivity phenomenaalopeciahand foot syndrome (combination therapy)haematological effectsoedemaGI upsethypertensionhypotensionneurosensory symptomsinjection site reactionlacrimation +/- conjunctivitisvisual effectsear, labyrinth disorders

Uncommon side effects of Taxotere:

heart failure (with anthracycline)chest painfebrile neutropeniathrombocytopenia

Reference:

MIMS Online. Taxotere. [cited 2007 October 30] MIMS Australia Pty Ltd 2006.

Diseases treated by Taxotere:

Breast Cancer (Inflammatory Carcinoma of the Breast) Breast Cancer (Pre-Invasive Ductal Carcinoma; Ductal Carcinoma In Situ; DCIS) Carcinoma of the Breast Lung Cancer (Adenocarcinoma of the Lung)


GN: Docetaxel

Con: breast cancer