Indication of Tenormin:
-Hypertension-Angina-Tachyarrhythmias-Myocardial infarction-Prevention of migraine
Action of Tenormin:
Atenolol, a type of beta-1-selective-beta-Blocker, competitively blocks beta- adrenoceptors in the heart, peripheral vasculature, bronchi, pancreas, uterus, kidney, brain and liver.The antihypertensive effect works by reducing cardiac output without reflex increase in peripheral vascular resistance; CNS effect and reduced renin secretionmay also contribute.The antianginal effect is due to reductionin left ventricular work and oxygen use, resulting from decrease in heart rate and contractility.The antiarrhythmic properties are due to antisympathetic effects: depression ofsinus node function and atrio-ventricular conduction and prolongation of atrial refractory periods.Atenolol, a beta-1-selective blocker, has a higher affinity for beta-1 receptors in the heart with less effect on beta-2 receptorsin bronchi and peripheral vasculature.
Dose Advice of Tenormin:
Hypertension, angina, migraine prevention: Oral: 25-100mg once dailyTachyarrhthmias: Oral: 50-100mg once dailyIV: 25mg (1mg/minute), repeate after 5 minutes if requiredIV infusion: 0.15mg/kg over 20 minutes; repeat after 12 hours if necessaryMyocardial infarction: Initially, IV 5-10mg (1mg/minute), followed by 50mg orally 15 minutes and12 hours later; then 100mg once daily for2 days. Maintenance, oral 50mg daily
Schedule of Tenormin:
S4
Common side effects of Tenormin:
-Nausea-Diarrhoea-Bronchospasm-Dyspnoea-Cold extremities-Exacerbation of Raynauds Syndrome-Bradycardia-Hypotension-Heart failure-Heart block-Fatigue -Dizziness-Abnormal vision-Decreased concentration-Hallucinations-Insomnia-Nightmares-Depression-Altered glucose and lipid metabolism
Uncommon side effects of Tenormin:
-Rash-Exacerbation of psoriasis-Impotence-Muscle cramp-Acute urinary retention-Nasal congestion-Hypersensitivity reaction-Thrombocytopenic purpura-Liver function abnormality-Alopecia-Cardiac arrest-Hepatic injury
