Thioprine



 
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Thioprine - Basic Information

 

Indication of Thioprine:

Azathioprine is used for the following indications: Immunosuppression in: Severe rheumatoid arthritis.Systemic lupus erythematosus.Dermatomyositis and polymyositis.Autoimmune chronic active hepatitis.Pemphigus vulgaris.Polyarteritis nodosa.Autoimmune haemolytic anaemia.Autoimmune thrombocytopenic purpura.Prevention of organ transplant rejection.Inflammatory bowel disease.Behcets syndrome.

Action of Thioprine:

Azathioprine is metabolised to form mercaptopurine which through altering purine synthesis impairs cellular immunity, depresses cell proliferation and inhibits cellular inflammatory responses.

Dose Advice of Thioprine:

The hematologic response should be monitored to guide dosing. Bone marrow suppression will limit the dose that can be given.The initial recommended dose is 2-3 mg/kg once daily given either orally or intravenously.Maintenance dosing is 1-3 mg/kg or the minimum dose required to control the disease or prevent transplant rejection.Renal impairment: Dose reductions may be necessary.Hepatic impairment: Dose reductions may be necessary.

Schedule of Thioprine:

S4

Common side effects of Thioprine:

Azathioprine suppresses the immune system and reduces inflammation.

Uncommon side effects of Thioprine:

- Increased susceptibility to viral, fungal and bacterial infections.- Hair loss.- Nausea and vomiting.- Diarrhoea.- Loss of apetite.- Mouth ulceration.- Inflammation of the Oesophagus.- Skin rashes.- Anaemia.

Diseases treated by Thioprine:

Crohns disease (Inflammatory Bowel Disease)  (Crohns Disease (Inflammatory Bowel Disease))


GN: Azathioprine

Con: Crohns disease (Inflammatory Bowel Disease)