Zocor

Indication of Zocor:

Used (in conjunction with diet therapy) for the treatment of high cholesterol (hypercholesterolaemia). Used in patients with or at high risk of coronary heart disease (e.g. patients with diabetes, a history of vascular disease), with or without high cholesterol, as part of risk factor control to reduce cardiovascular death.

Action of Zocor:

Zocors (Simvastatin) chief metabolite is a HMG-CoA reductase inhibitor, and therefore restricts the rate limiting step in cholesterol biosynthesis. Zocor only partially blocks cholesterol synthesis at an early stage, and so allows the production of the required amounts of cholesterol for biological functions, is not expected to cause an accumulation of potentially toxic sterols. Simvastatin is well absorbed after oral administration and undergoes extensive first pass metabolism with CYP3A4 Maximum plasma concentrations of active metabolites occur within 13-24 hours post dose.

Dose Advice of Zocor:

Dosage range: 10-80 mg/day Patients with or at high risk of coronary heart disease: 40 mg/day, as a single evening dose. Patients with hypercholesterolaemia and combined hyperlipidaemia: 10-20 mg/day as a single evening dose. Concomitant therapy: Zocor is effective alone, or if used in conjunction with bile acid sequestrants. The dose should not exceed 10 mg/day in patients taking immunosuppressive agents, gemfibrozil, other fibrates, or niacin. In patients taking amiodarone or verapamil, the Zocor dose should not exceed 20 mg/day. Impaired renal function: Renal excretion does not play a significant role in the drugs metabolism, however caution should be used in patients with severe renal insufficiency (creatinine clearance < 30 ml/min) and doses above 10 mg/day are should be carefully considered

Schedule of Zocor:

Schedule 4

Common side effects of Zocor:

Zocor is generally well tolerated, most side effects are transient and only mild. Abdominal pain, constipation, flatulence.

Uncommon side effects of Zocor:

Nausea, acid regurgitation, diarrhoea, dyspepsia, pancreatitis. Headaches. Muscle cramps, myalgia. Elevations of serum transaminases.

Diseases treated by Zocor:

Hypercholesterolaemia Nephrotic Syndrome (NS) Vascular Dementia (Multi-infarct Dementia)

Treatments associated with Zocor:

LDL (Low Density Lipoprotein) Cholesterol Lowering (LDL (Low Density Lipoprotein) Cholesterol Lowering) Statins (Statins)

• Lipex
• Zocor

• Nicotinic acid
• Pravachol
• Zocor

• Jezil
• Lipitor
• Nicotinic acid
• Vytorin
• Zocor